1/23/2024 0 Comments Nuclear charge of calcium![]() Phosphoinositide signalling enzymes in rat liver nuclei: phosphoinositidase C isoform β1 is specifically, but not predominantly, located in the nucleus. Epidermal growth factor-mediated activation of the ETS-domain transcription factor Elk-1 requires nuclear calcium. Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression. Hardingham, G.E., Chawla, S., Johnson, C.M. ![]() CBP: a signal-regulated transcriptional coactivator controlled by nuclear calcium and CaM kinase IV. Conformational states of the nuclear pore complex induced by depletion of nuclear Ca 2+ stores. Perez-Terzic, C., Pyle, J., Jaconi, M., Stehno-Bittel, L. Diffusion across the nuclear envelope inhibited by depletion of the nuclear Ca 2+ store. Synchronization of calcium waves by mitochondrial substrates in Xenopus laevis oocytes. Jouaville, L.S., Ichas, F., Holmuhamedov, E.L., Camacho, P. The Golgi apparatus is an inositol 1,4,5-trisphosphate-sensitive Ca 2+ store, with functional properties distinct from those of the endoplasmic reticulum. The versatility and universality of calcium signalling. ![]() The presence of such machinery provides a potential mechanism by which calcium can simultaneously regulate many independent processes in the nucleus.īerridge, M.J., Lipp, P. Our findings show that the nucleus contains a nucleoplasmic reticulum with the capacity to regulate calcium signals in localized subnuclear regions. ![]() Localized release of calcium in the nucleus causes nuclear protein kinase C (PKC) to translocate to the region of the nuclear envelope, whereas release of calcium in the cytosol induces translocation of cytosolic PKC to the plasma membrane. Stimulation of these receptors with a little InsP 3 results in small calcium signals that are initiated in this region of the nucleus. This network expresses inositol 1,4,5-trisphosphate (InsP 3) receptors, and the nuclear component of InsP 3-mediated calcium signals begins in its locality. Here we identify a reticular network of nuclear calcium stores that is continuous with the endoplasmic reticulum and the nuclear envelope. Calcium signals in the nucleus have effects on gene transcription and cell growth that are distinct from those of cytosolic calcium signals however, it is unknown how nuclear calcium signals are regulated. Calcium is a second messenger in virtually all cells and tissues 1. ![]()
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